A hungry adult Burm is a very dangerous animal. If it mistakes any part of your anatomy for food, it will strike and try to wrap around you. This will be unpleasant at best: although not venomous, a bite from a large constrictor can still send you to the emergency room with severed tendons and arteries. If it manages to wrap one or more coils around you it may very well kill you. Any Burm over 10 feet long should only be handled by two or more people: when dealing with a 15-foot+ Burm, it's best to have three on hand. This second person will be able to unwrap the Burm from the tail upward: sie can also use mouthwash or alcohol to cause the snake to let go and try to escape. If you live alone (or plan to do so soon), you really should think long and hard about getting a Burm. They may be uncommonly gentle wild animals, but they are still wild animals; if you forget that, you may get a very painful or even fatal reminder.

If you have other pets, you need to keep them safely away from your Burmese Python. This is for everyone's safety: a cat can maim a sleeping snake just as surely as a hungry Burm can swallow a teacup poodle. If you have children you should consider keeping your snake in a locked room: you should at the very least lock your cages to discourage curious toddlers. You should also be aware that you may be held criminally and civilly liable should your animal escape and cause damage. If your Burm kills the neighbor's dog you may be facing an expensive lawsuit; should it kill their baby you will likely be facing manslaughter charges. These scenarios may seem unlikely: it is in your best interest to make them impossible.